The main objectives of the present study are to examine self-efficacy and quality of life as a factor in influencing women entrepreneurs. Specifically, the current study deals with:Identify factors influencing women entrepreneursTo explore the extent of Self efficacy among women entrepreneurs of Andhra Pradesh. To study the extent of Quality of Life among women entrepreneurs of Andhra Pradesh. To examine the differences in the Self efficacy among women entrepreneurs based on demographic variables such as age, marital status, education, type of industries, and type of business and years of establishment among entrepreneurs.The hypothesis formulated in this study were the following:There will be a significant difference in self-efficacy among women entrepreneurs based on demographic variables such as age, marital status, education, type of industries, type of business and years of established.There will be a significant difference between demographical variables such as Age, Marital Status, Education, Type of Industries, Type of Business and modify in the same way as #1. Years of established with Quality of life among entrepreneurs. There will be positive relationship between Self efficacy and Quality of life among entrepreneurs.A descriptive design is considered appropriate to the present research, because accurate and original description is needed in order to identify the factors facing women entrepreneurs. Creswell (2003) gives more detail on the nature of descriptive research, saying that a number of different factors are required to characterize it.The target population of the present study are women entrepreneurs from different enterprisers in Andhra Pradesh. Since the study focus on women entrepreneurs, the sample of this study comprises of women from two different enterprisers in the state .The population of women entrepreneurs for this study included all women entrepreneurs in the manufacturing and services sector registered under the Small and Medium Industries Development Corporation (SMIDEC).The primary data were collected through mail survey using a self-administered questionnaire. This method was deemed most practical due to the geographically dispersed samples involved in this study. To answer the research questions developed, three main parts were used demographic information. The self-efficacy scale and the World Health Organization Quality of Life have been developed specifically for the purpose, the items for which were designed based on substantiation from previous research. The standardized instruments utilized for the present study are the following:The analysis process will be completely presented by using Statistical Package for Social Science (SPSS) version 20 as the tools to analyze all the data collected. The result of independent sample t test depicted that there is a highly significant difference among type of industry the participants are working and their quality of life along with significant difference in occupational self-efficacy where participants working in small scale industry showed higher mean value than medium scale industry. Result from one way ANOVA revealed that there is a significant difference found among Age Groups of the participants.Result indicated that there is a significant difference among participant education status and QOL where post graduates showed higher mean value followed by high schooled with respect to Quality of life.