Signs & Symptoms to Diseases: A Differential Diagnosis Guide for Medical Practitioners by Dr. Laxman M. Aneraye, first published in 2025, is a comprehensive and structured medical reference designed to strengthen the diagnostic reasoning of healthcare professionals. The book serves as a bridge between patient presentation and clinical decision-making, guiding practitioners from symptom recognition to precise diagnosis through systematic reasoning and evidence-based understanding.Organized alphabetically, the book presents a vast range ory of observation, logic, and interpretation stands at the heart of medical excellence.Organized alphabetically, the book presents a vast range of signs and symptoms encountered in outpatient and clinical settings. Each entry includes both subjective patient complaints and objective clinical findings, covering systems such as gastrointestinal, neurological, cardiovascular, respiratory, musculoskeletal, renal, hematologic, endocrine, and psychiatric. Examples include symptoms like abdominal pain, fatigue, fever, vertigo, hallucination, joint pain, loss of smell, and palpitations, each explored with meticulous attention to detail.Every symptom is analyzed through a tri-level framework of Very Common, Common, and Rare/Serious causes, enabling practitioners to prioritize diagnostic possibilities efficiently. This structure is supported by concise sections on associated features, investigations, and clinical reasoning—offering clarity not only in what diseases to consider but why they should be considered. For example, in the chapter on Acute Abdominal Pain, differential diagnoses span from gastroenteritis and appendicitis to peptic ulcer disease and ureteric colic, with logical diagnostic pathways and suggested investigations.The book draws on extensive reference material from globally recognized medical authorities, including Harrison’s Principles of Internal Medicine, Nelson Textbook of Pediatrics, Goldman-Cecil Medicine, and Robbins & Cotran Pathologic Basis of Disease. While modern AI-based tools were utilized to organize and classify data, all clinical interpretations and final reviews were manually verified by the author to ensure medical authenticity and diagnostic accuracy.A major strength of the book lies in its appendices, which serve as practical tools for everyday clinical use.Appendix 1 – Clinical Diagnostic Approach by System: Flow-based diagnostic reasoning for each organ system.Appendix 2 – Investigations and Diagnostic Value: Comprehensive interpretation of laboratory tests such as CBC, ESR, LFT, RFT, and electrolytes.Appendix 4 – Radiological and Imaging Correlations: Key imaging signs and their diagnostic implications, e.g., “apple core lesion” for colonic carcinoma or hyperdense CT area for acute intracerebral bleed.Appendix 5 – Emergency Management Protocols: Step-by-step guidance for handling acute emergencies like chest pain, seizures, shock, and anaphylaxis.Appendices 6 & 7 – Complete Drug Reference Tables: Extensive pharmacological compendium including modern, emergency, and integrative (Ayurvedic) therapies—such as the use of Vasaka and Tulsi in respiratory disorders.Beyond serving as a diagnostic manual, Signs & Symptoms to Diseases is a tribute to the enduring art of clinical reasoning—a skill that transforms observation into understanding and data into wisdom. It encourages physicians, residents, and medical students to look beyond investigations and cultivate the power of thought, synthesis, and human insight in medical practice.In an era of technological advancement and protocol-driven care, this work reminds practitioners that diagnosis is both a science and an art—a balance of intellect, intuition, and experience.