The emergence of Coronavirus Disease 2019 (COVID-19) marked an unprecedented global health crisis. This book offers an extensive clinical investigation into the revolutionary role of genomic variations—in both the SARS-CoV-2 virus and its human host—in shaping the pandemic.
From the outset, genomics was central to the global response, enabling the rapid identification of the novel coronavirus and tracing of its zoonotic origins. This volume delves into the relentless evolution of SARS-CoV-2, charting how genomic surveillance allowed us to track variants and understand their impact on transmissibility and disease severity. We explore the intricate host-pathogen relationship, examining how an individual's unique genetic makeup can determine their susceptibility to infection and risk of severe outcomes.