In summary, the present work concludes a simple and novel method for the
synthesis of Chalconyl incorporated Schiff’s bases without using any costly
chemicals and any drastic conditions. Melting points (°C) of the synthesized
compounds was determined in open capillary tubes and are uncorrected. The
homogeneity of compound was monitored by ascending Thin Layer
Chromatography (TLC) on silica gel G coated aluminum plates, visualized by
iodine vapor. IR absorption spectra were recorded on Bruker alpha KBr diffuse
reflectance. 1H NMR spectra were recorded on Bruker advance 400 NMR
spectrometer at 400 MHz. 1H NMR and IR spectra were consistent with the
assigned structures. LC mass spectra of the compounds were recorded on Water,
Q-TOF, Micromass (LC-MS).
Most of the compounds have displayed considerable antimicrobial activity as
indicated in Broth dilution method in comparison with standard drug. Compound
X4 showed significant antibacterial activity and rest showed poor activity against
the test. Therefore the nature of groups in chalcone moiety is very important for
antimicrobial activity. Compound X1 showed moderate antifungal activity while
the rest showed its absence. These new findings might be beneficial in future
research and development of Schiff’s bases containing chalcone nucleus as novel
antimicrobial agent.