The current work was done on drug Etoricoxib is BCS class II drug topical drug delivery management of RA. The present work uses the ingredients which so far is more suitable for the drug/diseases under consideration. Also these excipients combinations have not been tried so far. This will guide students working on topical formulations to have vision regarding uses of various excipients for proper formulation. This book also helps in understanding the role and characteristics of excipients in enhancing the formulation characteristics. In addition the aim of current work is to formulate the robust topical microemulsion containing etoricoxib which will be optimized by plotting various pseudoternary phase diagrams. Thus in the nutshell, the dissertation project differs from the patents and claims to be novel in its own. This book is for all those who want to move forward in topical drug delivery system in rheumatoid arthritis for better understanding of it.