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A concise handbook on exome sequencing for clinicians and clinical geneticists.
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Vinod Scaria is a clinician turned computational biologist. His laboratory is interested in understanding the function, organization and regulation of vertebrate genome, and how genomic variations could potentially impact them. He is also involved in creating novel methods and resources for analysis and annotation of genomes and understanding the functional impact of genomic variations. He has been part of collaborative genomics projects aimed at understanding the Asian Genome diversity. He has also been part of the whole genome sequencing and analysis projects including the Indian, Sri-Lankan and Malaysian genome projects and is also a member of the HUGO Pan-Asian Population Genomics Initiative task-force. He has adopted novel and creative strategies, such as the use of social media, and the participation of a large number of undergraduate students in collaborative projects to accelerate genome annotation and co-creation resources for genome annotation.
Vinod did his undergraduate medical education from Calicut Medical College, University of Calicut and PhD in Computational biology from University of Pune. Vinod has over 80 peer publications in international peer-reviewed journals and two book-chapters to his credit. He is also in the editorial board of PLoS ONE, PeerJ, Journal of Translational Medicine and Journal of Orthopaedics (Elsevier). He is also recipient of the CSIR Young Scientist Award for Biological Sciences in 2012. He was a member in the senate of the Academy of Scientific and Innovative Research (AcSIR)
Sridhar Sivasubbu’s laboratory is interested in exploiting the advantages of zebrafish to dissect molecular mechanisms of gene function, regulation and genome organization in vertebrates. Research activities in his lab include deciphering non-coding RNA mediated regulation of blood and blood vessel development and development of zebrafish models for application in personalized and precision medicine in humans. His group is actively involved in mapping the genome and transcriptome of the wild zebrafish. His group was also responsible for the whole genome sequencing of human samples from India and other Southeast Asian countries.
Sridhar did his PhD from M.S University, Tirunelveli, India and postdoctoral research at the Center for Cellular and Molecular Biology, India and the University of Minnesota, USA. He is a faculty at the CSIR-Institute of Genomics & Integrative Biology (CSIR-IGIB) since 2006. Sridhar also served as the CEO of The Center for Genomic Application, a Public-Private partnership company established by CSIR-IGIB for enabling research in the field of Genomics and Proteomics, where he spearheaded the application of next generation sequencing technology for commercial projects.