Alzheimer disease which is also known as AD is a neurodegenerative disease where the diagnosis in
time is very necessary so that the treatment is effective and well management. The recent methods are
based on a single type of data, which can be less effective. To overcome this, this paper proposes a
comparative multimodal framework for Alzheimer disease detection by using blood biomarkers,
cognitive assessment scores, MRIs and genomic information. Each of these modality is processed and
modeled independently for individual diagnostic contribution evaluation. This framework can be more
effective. It is conducted using python programming. Data processing and analysis is done using
standard libraries, including numpy and pandas. Model development and evaluation is done using
TensorFlow and keras. In this research we used publicly accessible datasets, like ADNI, OASIS and
NACC. The outcome shows that this framework is much more effective than existing techniques. This
approach is promising, non-invasive method to detect early Alzheimer.