ZOODISEASE: Understanding Diseases at the Human–Animal Interface explores the fascinating and complex world of zoonotic diseases and the biological connections between humans, animals, and the environment. The book introduces the fundamental concepts of zoonoses and explores their classification, modes of transmission, major bacterial, viral, parasitic, and fungal zoonoses, wildlife-associated spillover, vectors, emerging diseases, climate change, and prevention and control strategies. It also examines the ecological and epidemiological factors that influence disease emergence and transmission. A central theme of the book is the One Health approach, which recognizes the close interconnection between human, animal, and environmental health. Understanding zoonotic diseases therefore requires perspectives from zoology, microbiology, veterinary science, ecology, epidemiology, medicine, and public health. Written in a clear and accessible manner, ZOODISEASE is intended for undergraduate students, educators, researchers, and general readers seeking a foundational understanding of zoonotic diseases. It can also serve as a starting point for readers interested in exploring specific diseases and research areas in greater depth.